產(chǎn)品介紹

Stichodactyla toxin(ShK) 

K_v1.3 blocker（鉀離子通道K_v1.3阻斷劑）

ShK (Stichodactyla helianthus Neurotoxin) has been isolated from the venom of the Carribean sea anemone Stoichactis helianthus. ShK inhibits voltage-dependent potassium channels. It blocksK_v1.3 (KCNA3) potently and also K_v1.1 (KCNA1), K_v1.4 (KCNA4) and K_v1.6 (KCNA6) respectively with a Kd of 11 pM, 16 pM, 312 pM and 165 pM. Interestingly, it was also demonstrated that ShK potently inhibits the hK_v3.2b channel with an IC₅₀ value of approximay 0.6 nM.

Shk技術資料

氨基酸序列：

Arg-Ser-Cys³-Ile-Asp-Thr-Ile-Pro-Lys-Ser-Arg-Cys¹²-Thr-Ala-Phe-Gln-Cys¹⁷-Lys-His-Ser-Met-Lys-Tyr-Arg-Leu-Ser-Phe-Cys²⁸-Arg-Lys-Thr-Cys³²-Gly-Thr-Cys³⁵-OH

二硫鍵： Cys³-Cys³⁵, Cys¹²-Cys²⁸ and Cys¹⁷-Cys³² 

長度 (aa)： 35

分子式：C₁₆₉H₂₇₄N₅₄O₄₈S₇ 

分子量：4054.85 Da

外觀：White lyophilized solid

可溶性：water and saline buffer

CAS 號：165168-50-3

來源：Synthetic

純度：> 97%

產(chǎn)品信息