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Apamin（蜜蜂神經(jīng)毒素）
簡要描述：Smartox Biotechnology是*一家專門生產(chǎn)動物毒液多肽毒素，用于細(xì)胞離子通道功能研究的生物醫(yī)藥公司。多肽毒素在生物制藥領(lǐng)域具有重要的使用價值。
產(chǎn)品型號：08APA001- 廠商性質(zhì)：代理商
- 更新時間：2025-10-25
- 訪 問 量：1870
產(chǎn)品介紹
Apamin
Inhibitor of small conductance Ca2+-activated K+ channels
小電導(dǎo)鈣激活鉀離子通道抑制劑
Apamin is a neurotoxin that was originally isolated from Apis mellifera. Apamin binds to and inhibits the SK channels(small conductance Ca2+-activated K+ channels) in the brain and spinal cord. Apamin inhibits three subtypes of SK channels (KCa2.1, KCa2.2, and KCa2.3) with different affinity. Apamin does not affect KCa3.1 channel activity. Apaminmost likely acts as a pore blocker such as Scyllatoxin or Tamapin, although residues both inside and outside of the pore region of the SK channels participate in apamin binding. The SK channels are present in a wide range of excitable and non-excitable cells, including cells in the central nervous system, intestinal myocytes, endothelial cells, and hepatocytes.
Apamin 技術(shù)資料
氨基酸序列：
H-Cys1-Asn-Cys3-Lys-Ala-Pro-Glu-Thr-Ala-Leu-Cys11-Ala-Arg-Arg-Cys15-Gln-Gln-His-NH2
二硫鍵：Cys1-Cys11 and Cys3-Cys15
長度 (aa)： 18
分子式： C79H131N31O24S4
分子量：2027.34 Da
外觀： White lyophilized solid
可溶性：water and saline buffer
CAS 號： [24345-16-2]
來源： Synthetic
純度： > 98 %
產(chǎn)品信息
08APA001-00500 | Apamin | 0.5mg |
08APA001-01000 | Apamin | 1mg |
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